Fantasy Football Week 10 Start 'Em & Sit 'Em: Brock Purdy dominates as 49ers offense breaks out for good

Week 10 is here, and there are so many storylines for Fantasy managers to digest. I can’t wait to see how this scoring period unfolds.

At quarterback, it appears like Patrick Mahomes and Aaron Rodgers are back after both had big games in Week 9. But can you trust both of them in tough matchups in Week 10? Or is Daniel Jones against the Panthers in Germany a better starting option?

Christian McCaffrey (Achilles) is expected to make his 2024 debut in Week 10 at Tampa Bay, but is it safe to start him if he has a limited workload? And what about the Carolina backfield with Jonathon Brooks (knee) also set to make his debut against the Giants. Can we still trust Chuba Hubbard?

CeeDee Lamb (shoulder) is hurt and has a new quarterback with Dak Prescott (hamstring) out. Nico Collins (hamstring) and Jameson Williams (suspension) are expected to return. And Puka Nacua hopefully won’t throw any punches. There’s a lot to follow at receiver as always.

For the tight ends, Mike Gesicki is set up for a big game once again with Tee Higgins (quad) out, and Cade Otton has become a star. But what about guys like Jake Ferguson, Dalton Kincaid and Sam LaPorta, among others? Who are the tight ends to trust in Week 10?

As always, we’ll break down each position with who to start and who to avoid. Remember, four teams are on a bye in Week 10 (Seattle, Green Bay, Cleveland and Las Vegas), and it’s time to start thinking about the Fantasy playoffs.

Every win is important, so every lineup decision is crucial. Let’s get those rosters right for Week 10, and good luck in all of your leagues.

The last time we saw Purdy in Week 8 against Dallas he was having one of his best games of the season. He was 18-of-26 passing for 260 yards and a touchdown, and he added 56 rushing yards and a touchdown for 28 Fantasy points. It’s the second time in three games where Purdy scored at least 28 Fantasy points, but he’s yet to have consecutive games with 20-plus Fantasy points this season. That changes now.

Purdy is expected to get Christian McCaffrey (Achilles) and Jauan Jennings (hip) back for this Week 10 game at Tampa Bay, and this is a dream matchup. The Buccaneers are No. 2 in most Fantasy points allowed to opposing quarterbacks, and Tampa Bay has been lit up lately by Kirk Cousins twice (42.4 Fantasy points in Week 5 and 36.6 points in Week 8), Lamar Jackson (44.4 points in Week 7) and Patrick Mahomes (30.5 points in Week 9).

It’s Purdy’s turn now, and he should connect with McCaffrey, Jennings, Deebo Samuel and George Kittle for a huge outing. I like Purdy as a top-six quarterback in Week 10, and this should be one of his best performances of the season.

Eagles (at DAL)

The Eagles defense is playing well heading into Week 10 at Dallas, and now Philadelphia gets a favorable matchup against Cooper Rush with Dak Prescott (hamstring) out. In the past four games, the Eagles have allowed 17 points or less in each outing against Cleveland, the Giants, Cincinnati and Jacksonville with 24 sacks, three interceptions and two fumbles over that span. The Cowboys have allowed nine sacks in the past three games, and the Eagles DST could be the No. 1 unit in Week 10.

• Bears (vs. NE)
• Lions (at HOU)
• Giants (at CAR)

Saints (vs. ATL)

The Saints DST was a major letdown in Week 9 at Carolina with one sack, one interception and 23 points allowed. New Orleans just traded standout cornerback Marshon Lattimore to Washington on Tuesday, and the Saints will likely struggle to stop the Falcons in Week 10. Atlanta has scored at least 26 points in five of the past six games, and the Falcons have just five turnovers since Week 5, with seven sacks allowed over that span. In Week 4 against the Saints, the Falcons scored 26 points with one sack and one interception, but I wouldn’t trust the Saints DST in most leagues in the rematch.